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unc 51  (Proteintech)


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    Structured Review

    Proteintech unc 51
    Unc 51, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 169 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/unc 51/product/Proteintech
    Average 96 stars, based on 169 article reviews
    unc 51 - by Bioz Stars, 2026-03
    96/100 stars

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    Image Search Results


    Chaperonin-containing tailless complex polypeptide 1 subunit 6A affects the autophagy pathway in colorectal cancer cells. A and B: Cell lysates were extracted from knockout (KO)-Control (Ctrl) and KO-chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) HT29 cells, as well as overexpression (OE)-Ctrl and OE-CCT6A SW480 cells, and then subjected to immunoblotting using the indicated antibodies; C: Following treatment with chloroquine diphosphate salt (CQ, 20 μM, hereafter unless otherwise indicated) for 2 hours, immunoblotting was performed with the total proteins extracted from the indicated cells. DDP: Cisplatin; LC3: Light chain 3; mTOR: Mammalian target of rapamycin; Ulk1: Unc-51-like autophagy activating kinase 1.

    Journal: World Journal of Gastroenterology

    Article Title: Chaperonin-containing tailless complex polypeptide 1 subunit 6A negatively regulates autophagy and protects colorectal cancer cells from cisplatin-induced cytotoxicity

    doi: 10.3748/wjg.v31.i18.105729

    Figure Lengend Snippet: Chaperonin-containing tailless complex polypeptide 1 subunit 6A affects the autophagy pathway in colorectal cancer cells. A and B: Cell lysates were extracted from knockout (KO)-Control (Ctrl) and KO-chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) HT29 cells, as well as overexpression (OE)-Ctrl and OE-CCT6A SW480 cells, and then subjected to immunoblotting using the indicated antibodies; C: Following treatment with chloroquine diphosphate salt (CQ, 20 μM, hereafter unless otherwise indicated) for 2 hours, immunoblotting was performed with the total proteins extracted from the indicated cells. DDP: Cisplatin; LC3: Light chain 3; mTOR: Mammalian target of rapamycin; Ulk1: Unc-51-like autophagy activating kinase 1.

    Article Snippet: Primary antibodies against CCT6A (19793-1-AP), tubulin (66240-1-Ig), phosphorylated Unc-51-like autophagy activating kinase 1 (phospho-Ulk1) (Ser556, 80218-1-RR), Beclin-1 (11306-1-AP), and p62 (66184-1-Ig) were purchased from Proteintech Group (Wuhan, China).

    Techniques: Knock-Out, Control, Over Expression, Western Blot